Solving major societal issues requires intensive collective efforts from universities, in close collaboration with societal partners. The three universities can, by leveraging their high scientific quality, the breadth of their largely complementary portfolios, and their proximity to each other, collaborate inter- and multidisciplinarily on regional, national, and global challenges. They do this within four societal themes: Sustainable Society, Inclusive Society, Healthy Society, and Digital Society. These themes provide guidance for current and future education and research within the LDE partnership.